Vmware vSphere ESXI 8.0
vCenter 8.x
vCenter 9.x
In a VMware VMM-integrated Cisco ACI environment, vCenter is not in the data path for actual vMotion traffic (which travels directly between ESXi hosts). However, since Cisco ACI controller is leveraging the vSphere APIs, if vCenter goes unresponsive due to any reasons, it may affect the policy updates in underlay networking.
Fix the issue associated with low disk space in vCenter and ensure vCenter is healthy and then monitor and see if it helps to resolve the network issue.
Refer KBs;
vCenter root partition filling up due to excessive logging in /var/mail/root file
Cisco ACI VMM integration is a partner integration that has no clear demarcation point. Due to the operational nature of this integration, Broadcom requires issues to be reproduced in an environment free of the partner component to confirm if the root cause lies within vSphere or NSX.
In cases where there is no clear demarcation line,* Broadcom will require the following two steps to troubleshoot or manage issues related to vSphere, NSX-T, or NSX environments. Broadcom will request the creation of an environment free of the partner component in question** for troubleshooting purposes.
Refer: Intermittent network disconnects on virtual machines using Cisco ACI VMM integration