Lookup plugins work for a period of time, but then fail suddenly.
You have already confirmed that the Issue is resolved after reloading the lookup plugin.
Symantec Data Loss Prevention
This issue can be caused by a timeout in the length of time to run the lookup.
For example an LDAP lookup with very large result set can timeout before completion and trigger an unload of the plugin then subsequent lookups may fail.
Modify the Lookup Plugins property file to automatically reload the lookup plugins daily as this may help reduce or eliminate the issue.
Important Note: Before modifying any file, make a backup/copy of the file as you can then restore the backed up version should you run into any issues.
See also Troubleshooting lookup plug-ins