This page describes how to change the location of the SMSMSE quarantine directory by using Windows Operating System Mount points.
There is a defect in versions 6.0.0 through 6.0.8 where it is not possible to change the Quarantine directory in the product.
Upgrade to SMSMSE version 6.0.9 or higher. Then use the following article: Changing the location of the Quarantine directory for Symantec Mail Security for Microsoft Exchange (SMSMSE).
It is possible to use the Quarantine folder as a mount point for another partition. using the steps below.
WARNING: Using the partition to store other data may cause loss of that data or may cause the SMS MSE Quarantine to function incorrectly.
Note for Clustered Environments:
When SIFMS MSE is successfully installed in a Microsoft Exchange cluster, the quarantine is stored on the cluster's shared storage rather than on each node's C:\Program Files\Symantec\SMSMSE\6.0\Server\Quarantine directory. When the cluster fails over from node to node, it will still have the ability to release all mails from quarantine.
Options available in case the Quarantine size is not sufficient.