On Windows 10, an application launched from a Windows user's profile directory such as C:\Users\Firstname_Lastname\AppData\MyApplication.exe does not work as expected when Symantec Endpoint Protection (SEP) is installed with Application Control enabled. The application may appear to hang or freeze for some period of time.
You create and apply an Exception Policy for Application Control using the optional predefined prefix [USER_PROFILE], but that does not resolve the issue.
An Exception Policy for Application Control without the [USER_PROFILE] prefix, but with the absolute path such as C:\Users\Firstname_Lastname\AppData\MyApplication.exe does resolve the issue.
Symantec is aware and currently investigating this issue. This document will be updated when more information is available.