On servers with more than 8 logical processors, you may experience InsufficientMemoryException (this exception inherits from OutOfMemoryException) errors or degraded performance when running .NET 2.0 - based applications such as Symantec's ITMS products.
System.InsufficientMemoryException or System.OutOfMemoryException being thrown from w3wp.exe, aexsvc.exe or other .NET processes.
See Microsoft KB974065
These issues were first resolved with a Limited Distribution Release hotfix KB974065 (file versions - 2.0.50727.4062) from Microsoft referred to here:
These fixes are also contained in a publicly available fix - KB981574.
Recommended Steps to install fixes mentioned above, and additional performance related fixes:
Windows Server 2003, 2008 and 2008 R2 running .NET 2.0 SP2 builds prior to 2.0.50727.4062
Server 2008 R2 Service Pack 1 includes these fixes so is unaffected.