Symantec has tested the September 20, 2016 release of macOS 10.12 and confirmed support with the version 14.5 DLP Agent. All Endpoint Discover and Endpoint Prevent features are supported on that release, with the exception of Chrome and Safari browser monitoring.
Endpoint Prevent support for the Chrome and Safari browsers for macOS 10.12 is now available via a hotfix for DLP 14.5 MP1.
Please contact support for details on obtaining and applying this hotfix.
For further updates on the Safari and Chrome support status, subscribe to this Support Center article.