Symantec Drive Encryption (previously PGP Whole Disk Encryption) is unable to encrypt a drive with 4K Native sector size.
Usually no error is displayed for this problem. However, when selecting PGP Disk through the Symantec Encryption Desktop user interface, the drive will not appear as a drive to encrypt. In addition, an unknown error (11980) may occur when trying to encrypt the drive.
This is a known limitation of Symantec Drive Encryption as the application does not currently support 4K Native sector drives. There are no plans to include 4K Native support for Symantec Drive Encryption.
Since Symantec Encryption Desktop 10.4.1, this issue no longer appears to be an issue. If any further issues are observed, please log a ticket with Symantec Support to review further.
Previous historical notes on this issue.
Drives with native 512-byte sectors are supported. Many 4K drives with 512-byte sector emulation (commonly referred to as 512e, or Advanced Format Drives) are also supported. To determine the disk drive's sector size please refer to the Related Articles.
Symantec Endpoint Encryption 11 is currently being reviewed to include 4K Native support for encryption in a future release. Please be sure to refer back to this document periodically as any changes to the status of the request will be reflected here.
A Feature Request was submitted to Symantec Development on this functionality. For more information on this Feature Request, see KB article TECH200098.
To find out if your system is using 4K Native Sector Size, please see article TECH198917.