VFFS is a derivative of VMFS, which is optimized for SSDs and is used to group the physical SSDs into a single caching resource pool. It is a non-persistent resource and, therefore, virtual machines cannot be stored in it.
A VFFS resource pool can be created from mixed resources. All devices types are treated the same and no distinction is made between SAS, SATA, PCI express connectivity.
Note: You must consider any other differences in read/write speeds when creating a VFFS from mixed SSDs and group similar performing devices together to maximize performance.