VMware vSphere ESXi 6.X
VMware vSphere ESXi 7.x
None. If you do not plan to use vCPU hotplug, do not enable it. Add the maximum vCPUs that might be needed by the workload. In rare cases, where vCPU hot plug is required, try to limit the maximum number of vCPUs to stay below the physical NUMA node core count so that the virtual machine can be scheduled in a single NUMA node.
Steps to Enable/ Disable CPU Hot Add: