When the Windows System Assessment Scan runs on the agent it fails with an exit code of -2147467259 or 9009.
The related informational messages that are generated in the agent logs are below.
The computers are not targeted by an enabled software update plug-in policy which is required for the the Software Update Agent to be ready.
Note:
Also, no having the proper target (by default "Windows Computers with Software Update Plug-in Installed Target" ) under "Windows Patch Remediation Settings" (under Settings>Software>Patch Management) can cause issues.