This article provides troubleshooting steps when LUNs are missing:
VMware Skyline Health Diagnostics for vSphere - FAQ
"Host Connectivity Degraded in ESXi" warning in vCenter Server
"An error occurred while consolidating disks" when deleting one or more snapshots or consolidate disks
Resolving SCSI reservation conflicts
Troubleshooting fibre channel storage connectivity
Obtaining LUN pathing information for ESXi hosts
Performing a rescan of the storage on an ESXi host
Using esxtop to identify storage performance issues for ESXi (multiple versions)
Interpreting SCSI sense codes in VMware ESXi