1. This can be achieved by adding manage Transport Properties/ Headers assertion to your policy.
2. In the Transport Properties/ Header Properties set the type to HTTP
3. In the Transport Properties/ Header Properties change the operation to add or replace
4. In the Transport Properties/ Header Properties the Property/Header name should be set to X-Content-Type-Options
5. In the Transport Properties/ Header Properties value set the value as nosniff
6. Additionally you can add this to a global fragment as well.