Error 6 initializing SQL*Plus on instance clients.
Jobs that are run on an instance client fail with the following error messages:
Error 6 iitializing SQL*Plus
SP2-0667: Message file spllang.msb not found
SP2-0750: You may need to set ORACLE_HOME to your Oracle software directory
It is also not possible to log into SQL*Plus after invoking the sosite file with the same error message.
CA Automic Applications Manager
The sosite file contains a line that sources in the sqloper.ini file which resides in the $aw_home/bin directory ($AW_HOME/bin/sqloper.ini). The sqloper.ini file contains a section that sets the LIBPATH to include $aw_home/c. Prior to running the sosite file, the variable LIBPATH does not exist in the environment. LIBPATH has meaning in the oracle world and would typically be set to something like this: $ORACL_HOME/lib32.
The instant client does not require an ORACLE_HOME environment variable (per the oracle documentation) but oracle still seems to reference somewhere in the sqlplus distribution provided for the instant client. When it does not see an ORACLE_HOME the error above is thrown.
The solution is to set LIBPATH to the same value as the instant client home directory in the sosite file prior to sourcing in the sqloper.ini as follows:
LIBPATH=$LD_LIBRARY_PATH; export LIBPATH
. $AW_HOME/bin/sqloper.ini