No, if you do, you will need to exclude NetQoS directories; D:/netqos and the C:/windows/temp directory.
Failure to do so can result in unpredictable results, such as errors in the web and corruption of the MySQL database. If it's not acceptable to you, then you can risk having errors or corruption in the product.
This is our recommendation, but ultimately it is up to you decide to or not. If you don't then CA will not be able to resolve issues stemming from failure to follow our recommendations.
It is also a MySQL recommendation to exclude MySQL from antivirus scan, the article below explains why:
See also, CA tec doc > TEC574279