If the NX_ROOT\NX.ENV file has been manually edited using a text editor, it can cause improper characters to save in file, causing corruption.
This causes the system to throw Debug Assertion Failure errors when any CA Service Desk Manager executable is executed.
CA Service Desk Manager - all versions
To prevent this problem from happening, always use either OPTIONS MANAGER or the PDM_OPTIONS_MGR command to update NX.ENV variables.
If the problem is already occurring, the best way to remediate it would be to locate the most recent backup from the same machine where the problem is occurring and restore the NX_ROOT\NX.ENV file.
Remember you CANNOT copy the NX.ENV file from one system to another as it has hashed values stored that will not be read by other systems.