ESXi hosts may enter a "Not Responding" state, rendering hosted VMs inaccessible. Symptoms include logs reporting "No space left on device" for the OSDATA partition and "APD Notify PERM LOSS" (All Paths Down) events in the vmkernel.log.
VMware vSphere ESXi 8.x
The OSDATA partition becoming full prevents the ESXi host from performing essential management tasks. Concurrent storage fabric or array instability triggers APD/PDL conditions, causing the host to stop responding as it attempts to retry I/O operations.
vdf -h to check the OSDATA partition.