VMware NSX
The root cause is identified as Physical Host Resource Contention. When an ESXi host experiences high CPU ready times or is oversubscribed, the NSX Edge node which relies on low-latency CPU scheduling to maintain datapath throughput experiences performance degradation.
The "High Datapath CPU" alerts in NSX are a secondary symptom of the Edge struggling to process traffic due to these scheduling delays.
To isolate the issue to the ESXi host: