VMware vSphere ESXi (all versions)
Datastore creation fails becausse there is a MTU mismatch between the vmkernel ports used for iSCSI and the vSwitch. Specifically, while the iSCSI vmkernel ports have MTU of 9000, the vSwtich has an MTU of 1500.
vmkping -I <vmkernel_port> -d -s 8972 <target_IP>