ZTNA.
Cloud SWG.
Administration Console.
DLP.
Cloud SWG DLP policy blocking access to uploaded ZTNA configuration.
Change DLP policy to allow uploaded requests to the ZTNA Portal.
ZTNA admin made changes earlier in the day from the office, but the changes that gave the error were from the admin's home network.
Looking at the HAR file at the time of the issue showed the PUT (HTTP method used to push updates to ZTNA) request to update the policy (policy ID masked out below for security reasons) returned an error in the payload that indicated a DLP block (data_leak_detected).
Data leak messages are usually returned from a DLP policy when going through Cloud SWG.
Confirmed that the ZTNA admin was indeed sending traffic via Cloud SWG using the WSS Agent (active for all users outside of the office).
Logging into their Cloud SWG tenant, we confirmed that all HTTP requests using the PUT method were blocked with the data_leak_detected verdict.
Modifying the DLP policy to allow these requests through addressed the issue.