VMware vSphere ESXi (all versions)
Intermittent I/O latency either at the storage array or network/fabric level.
To confirm, when issue is occuring, run:esxtop
Type 'u' to select device view and confirm DAVG/cmd metrics.
For further informationon interpreting esxtop data, see: Using esxtop to identify storage performance issues for ESXi.
Investigate the cause of the latency spikes on the storage array and network/fabric, and resolve.