When adding a new virtual hard disk to a Windows guest OS the drive appears in Windows Disk Management.
The new virtual hard drive can be initialized using GPT or MBR.
The new virtual hard drive can be formatted using NTFS or ReFS and assigned a drive letter.
When attempting to access the new virtual hard drive from Windows Explorer, you receive an access denied error message:
Location is not available
X:\ is not accessible
Access is denied
Environment
VMware ESXi 6.x VMware ESXi 7.x VMware ESXi 8.x
Cause
This is caused by the guest operating system and/or security software installed on it preventing interaction with the new virtual hard drive. The guest OS and/or security software sees the new virtual hard drives as portable devices presented to the guest OS as per the Windows Device Manager:
Resolution
As a workaround for Windows guest operating systems, you can follow the steps outlined in KB 367422 to mask the guest OS from seeing removable devices.