You observe the following symptoms in your environment:
VMware vSphere ESXi
The underlying cause is a scheduled "storm" of network traffic originating from within the Horizon virtual desktops. This is typically triggered by synchronized automated tasks, such as weekly security scans, antivirus signature updates, backups, or system-wide patch checks, that occur simultaneously across the environment. This synchronization saturates the firewall's session capacity, leading to session-table exhaustion or CPU saturation on the network appliance. This is not a VMware issue but the effect may occur due to the volume of network traffic and the physical firewalls capacity to process applied volume.
To resolve this issue, you must reduce the concurrent pressure on the network appliance by de-synchronizing automated guest-level tasks.
For additional guidance on troubleshooting network performance, see
Troubleshooting network performance issues in a vSphere environment