Virtual machines experience slow network data transfer or high latency when communicating across different datacenters.
A physical network constraint or latency bottleneck on the external infrastructure or circuit connecting the datacenters, rather than a performance degradation within the ESXi host or virtual machine.
Verify Traffic Shaping is disabled on the relevant vSphere Distributed Switch (vDS) or Standard Switch portgroups via the vCenter Server UI.
Establish an SSH session to the ESXi host where the affected virtual machine resides.
Run esxtop, press n to access the networking view, and verify that the %DRPTX and %DRPRX columns display 0.00 to confirm the virtual machine is not actively dropping packets.
Identify the active uplinks for the virtual switch and run esxcli network nic stats get -n vmnicX (replacing X with the vmnic number). Verify there are no actively incrementing dropped packets or receive missed errors.
If ESXi network statistics show no drops, perform bandwidth baseline testing using iperf between two virtual machines residing on the same ESXi host.
iperf is a tool for active measurement of the maximum achievable bandwidth on IP networks.
Perform iperf testing between virtual machines on different ESXi hosts within the same datacenter to validate local physical switch performance.
Perform iperf testing between the virtual machines across the different datacenters.
If the bandwidth drops significantly only during the inter-datacenter test, engage the physical network team to inspect the interconnecting circuit.