You may observe the following symptoms and behaviors when troubleshooting:
The CTRL + ALT + DELETE command fails when accessing the VM console of Windows Servers through the vSphere Client (vCenter web console), the ESXi Host Client, or the VMware Remote Console (VMRC).
The problem is isolated to a single VM. Other VMs residing on the exact same ESXi host function normally and respond to console commands.
You can successfully connect to the affected VM using Remote Desktop Protocol (RDP), where the CTRL + ALT + DELETE command functions correctly directly within the guest operating system.
When the affected VM is booted into Safe Mode, the CTRL + ALT + DELETE console command works as expected.
The exact root cause requires further isolation. Because the command works in Safe Mode and via RDP, the issue likely stems from either a conflicting service/driver within the normal Guest OS image, or an issue specifically tied to the virtual keyboard device.
This is a condition that may occur in a VMware vCenter environment.