This article provides technical guidance on deploying vSAN across multiple racks using a physical VXLAN underlay (Layer 2) as well as the integration of VMware NSX with vSAN.
VMware vSAN 8.x
VMware vSAN 9.x
VMkernel traffic is not supported over the NSX-managed VXLAN overlay is to avoid any circular dependency between the VMkernel networks and the VXLAN overlay that they support. The logical networks delivered with the NSX-managed VXLAN overlay are used by virtual machines, which require network mobility and flexibility.
Reference the documentation for Using VMware NSX with vSAN.
Reference the documentation for vSAN Networking Requirements guide.