VMware ESXi with Dual DPUs.
VMware ESXi 8.0 Update 3i and previous 8.0 releases
When a vmkernel adapter is added to an ops or mirror netstack on a dual DPU host, it is deployed on the DPU side and is not visible under the host's "TCP/IP configuration" tab in the vCenter Server UI.
Due to this design, default routes overridden during vmknic creation do not properly persist through the standard host configuration upon reboot.
This is a known issue impacting VMware vSphere ESXi.
If you encounter this issue, please open a Broadcom support case using the instructions at KB 142884 - Creating and managing Broadcom cases