Symptoms:
"Fault occurred while performing health check. Details: 'Connect: Input/output error'."
"A replication error occurred at the vSphere Replication Server for replication '###'. Details: 'No connection to VR Server for virtual machine ### on host ### in cluster ### in ###: Unknown'"
VMware Live Recovery 9.X
The issue is caused by the lack of support for enabling or routing vSphere Replication traffic over a custom TCP/IP stack on ESXi hosts. vSphere Replication communication is supported exclusively over the default TCP/IP stack. Consequently, attempts to bind replication traffic to a VMkernel adapter associated with a custom stack result in connectivity failures during health checks and replication broker communication.
vSphere Replication traffic isolation can be achieved through the following methods
1.Tagging a VMkernel adapter on the default TCP/IP stack for vSphere Replication traffic
2. Configuring static routes to direct replication traffic through the intended network path.
Refer the Broadcom tech document for more information on isoltaing vsphere replication traffic :