VMware ESXi
Window network communication failures where data packets can't be sent properly, often seen as "Ping: transmit failed. General failure." in Windows, can stem from incorrect IP settings, firewall blocks, bad network drivers, 3rd-party security applications installed in the OS, or hardware issues. This error indicates your device can't find the route or isn't allowed to send the data
This "General error" indicates the Operating System was unable to send the network packet for one reason or another and investigation needs to occur within the OS.
For a known possible cause for this error, see Ping attempts from the Windows VM resulted in a 'General Failure' error when a security software agent is installed in the guest Operating System.
For additional troubleshooting recommendations, see Troubleshooting and understanding physical NIC receive or transmit dropped, missed and error counters in ESXi.