This is caused by a behavioral change introduced with Uniform Passthrough v2. In vSphere 8.0 Update 2, VMXNET3 adapters are "DirectPath-ready" by default. The uptCompatibility setting is enabled in the VM configuration, which prevents some backup proxies from successfully performing hotadd operations on the virtual machine.
If the ESXi host does not have a SmartNIC, the UptCompatibility setting can be safely disabled. To restore hotadd functionality in these cases, the uptCompatibility feature can be disabled within the virtual machine configuration (VMX) file.
esxcli vm process list | grep -i "<VM Name>"
vi /vmfs/volumes/<datastore>/<VM-Name>.vmxethernet0.uptCompatibility = "TRUE" and change the value to "FALSE".wq! and exit the editor.vim-cmd vmsvc/getallvms | grep "<VM-Name>"vim-cmd vmsvc/reload <Vmid>