Traffic initiated from virtual machines connected to NSX segments toward external networks does not receive a response (for example, ICMP) so it fails.
VMware Cloud Director
Traffic from virtual machines connected to NSX segments matched a Default SNAT rule on the Edge Gateway while NAT was also configured on the NSX Tier-1 Gateway.
The observed traffic was translated more than once before leaving the NSX Edge, resulting in a source address that upstream or physical network devices were not expecting, which prevented return traffic from being handled correctly.
Review the NAT configuration along the outbound traffic path, including NAT defined on the Edge Gateway (Default Autoconfiguration SNAT and any manual NAT rules), the NSX Tier-1 Gateway, the NSX Tier-0 Gateway if applicable to understand how traffic is translated before leaving the NSX Edge.
Use NSX Traceflow to trace the traffic and confirm whether traffic is being NATed more than once and which source address is used when traffic leaves the NSX Edge.
For additional reference see:
Autoconfigure Default NAT and Firewall Rules on a Provider Gateway in Your VMware Cloud Director