"Unexpected error while upgrading upgrade unit. Host https://<host_ip>/sdk not reachable. java.net. NoRouteToHostException: No route to host (Host unreachable)"VMware NSX
If there are 2 management VMkernel adapters with different IPs, NSX manager selects any one of the IP to connect.
Reference KB for the communication issue between the host and NSX manager (No route to host): Unable to install NSX-T packages on a specific ESXi host