In VMware ESXi environments using IP-based storage (iSCSI, NFS, or NVMe over TCP), redundancy is often configured using two VMkernel (VMK) interfaces. However, if both interfaces reside on the same subnet, traffic may fail to fail over to the redundant link during a physical uplink or switch failure. This results in storage connectivity loss, with paths showing as "Dead" or "Timed Out." Monitoring tools may show TCP sessions stuck in a SYN_SENT state as the ESXi NetStack continues attempting to use the original initialized interface.
SYN_SENT instead of ESTABLISHED.vmkping from the secondary interface may succeed, but active I/O does not resume.Choose the appropriate resolution path based on the storage protocol and driver in use.
For iSCSI, explicitly bind each VMkernel interface to the Software iSCSI Adapter to enable Multipathing (PSP).
Since NFS and the SCINI driver do not support Port Binding, use separate subnets to ensure failover.
If a single subnet must be used and Port Binding is unavailable:
If using multiple uplinks under a single VMK:
For more information refer to the kb : Multihoming on ESXi