You are performing maintenance updates on your infrastructure and want to know if you should upgrade the virtual hardware compatibility on the vCenter Server Appliance or other VMware appliances (such as NSX Manager), similar to how you upgrade standard Windows or Linux workload virtual machines.
VMware appliances are distributed as pre-packaged solutions with a specific virtual hardware configuration that has been validated by engineering. Modifying this configuration can introduce unknown variables, instability, or complicate troubleshooting.
For further guidelines on best practices around upgrades, see Keeping a vSphere environment up to date.