VMware NSX
NSX 4.2 exclusively supports certificates compliant with OpenSSL 3.0 standards.
This change primarily affects "brownfield" (existing) environments. If your current Pool member configurations utilize only any of these unsupported TLS versions (TLS1.1 and TLS1.2).
openssl s_client -connect <poolmember-ip>:443 -tls1_2
Detailed compatibility requirements and OpenSSL 3.0 are documented in KB 368005.