Does vSphere Replication replicate advanced parameter changes, or need manually changing on failover?
VMware vSphere Replication 9.x
vSphere Replication is primarily focused on vmdk( disk ) replication, thus on the RPO it syncs data that has changed in the vmdks disks themselves.
If you make a change to the protected VM advanced settings, vSphere Replication requires a "Sync Now" task to update the vmx on target.