VMware NSX
SSL handshakes can fail when the configured MTU settings are mismatched between the client and server causing packet fragmentation.
Isolate where the packet fragmentation is occurring and adjust the configured MTU as appropriate to prevent it from occurring.
For assistance with this in NSX, refer to Troubleshooting MTU issues and fragmentation in NSX fabric.
For a similar issue causing this status, see Server pool in Degraded state after upgrading to NSX 4.2.x (SSL or TCP Handshake Timeout error as per Edge logs).