VMware ESXi
VMware vCenter Server
The ESXi host is unable to determine the correct egress path for traffic destined for the vCenter Server IP address. This typically occurs in environments with multiple VMkernel adapters on different subnets where a specific static route is required to bypass an incorrect default gateway selection or a lack of routing information for the management network.
To resolve this issue, you must add a static IPv4 route to the ESXi host to explicitly define the gateway for vCenter Server traffic.
esxcli network ip route ipv4 add --gateway xx.xx.xx.xx --network ##.##.##.##/24
esxcli network ip route ipv4 add --gateway xx.xx.xx.xx --network <vCenter_IP>/32esxcli network ip route ipv4 list OR esxcfg-route -l