If you're seeing the error "451 4.4.62 Mail sent to the wrong Office 365 region. ATTR35 [No TLS]" on your Symantec Messaging Gateway (SMG), it means that Office 365 is rejecting the email, not SMG. This occurs when emails are sent to the wrong Office 365 region or when TLS encryption is missing.
No TLS: If the email isn't encrypted with TLS, Office 365 might block it.
Contact Office 365 Support: Reach out to Microsoft to confirm the correct region and to verify any TLS requirements.