The Core Prevention policy rules will DENY or TERMINATE processes based on their target file reputation; however, the Core Prevention exclusions only have the ability to include Parent Processes and Processes, which does not prevent the rule from applying.
Processes like command interpreters can execute scripts and fileless actions that match Core Prevention rules, but the target of the block action is not the Process (cmd interpreter) itself.
The Core Prevention Exclusions functionality is not going to be relevant to preventing the DENY or TERMINATE actions in some situations because the CBC console only provides options to exclude the PARENT PROCESS or the PROCESS value and not the TARGET value.
WORKAROUND:
Core Prevention Exclusion improvement is a feature request that has been in the works for a while and with the next feature update for Core Preventions we do expect to add this functionality to include target files to prevent them from triggering Core Prevention policy.