The upgrade of NSX from the version required by VCF 4.5.1 to VCF 5.2.1 recommends running the NSX Upgrade Evaluation Tool. This is built into the NSX 4.2.1 upgrade components, but SDDC Manager is unable to execute the precheck. This requires the upgrade of NSX to be performed by the NSX interface. Once the upgrade completes, SDDC Manager must be updated to recognize the upgrade is complete and the error has been addressed.
The SDDC Manager database will need to be updated to mark the upgrade of the NSX components as complete. Please open a case with Broadcom Support for assistance.