"Not Responding" in vCenter.vpxd.logs at /var/log/vmware/vpxd/ shows missing heartbeats timed out between vCenter & ESXi hosts.VMware vCenter Server
VMware ESXi
'Network latency' between ESXi and vCenter can affect their connectivity, ultimately causing the hosts to appear in a "Not Responding" state.
ESXi host and vCenter connectivity can be affected by network issues, particularly latency, which can lead to missed heartbeats. To diagnose network and latency problems, packet captures and traceroutes should be performed on the physical infrastructure.
To perform the packet capture on ESXi, please refer - Packet capture on ESXi using the pktcap-uw tool