An ESXi host may find a datastore rendered inaccessible following a reboot or storage rescan (e.g., after patching) if the underlying VMFS partition was deleted prior to the host performing these actions. The partition table is physically located on the LUN, this change is visible to all vSphere hosts with access to that LUN. However, only the hosts that perform a rescan/reboot will be affected
Resolution
Recreate the VMFS Partition table and perform a cluster-level rescan.