VMware ESXi 8.x
VMware vCenter 8.x
VMware vSAN
Changing the MTU of component that generates traffic, such as a vmkernel adapter, to be larger than the MTU of whatever passes that traffic, such as the vSwitch or a physical switch, will lead to fragmentation and drops.
Please note that most vendors require the physical network MTU to be set higher than the vSphere environment to allow for overhead, for example the physical switch MTU may need to be set to 9216 for a vSphere MTU value of 9000. Please refer to vendor documentation for specific values based on the infrastructure in-use.