Editing a firewall rule from the vCenter GUI, for a specific ESXi host within vCenter, results in the ESXi host entering 'Not Responding' state. This may also impact VMs, rendering them inaccessible.
From the hostd logs presented in an SSH to the host, within /var/log directory, you will notice the below message:
--> eventTypeId = "esx.audit.net.firewall.config.changed",
The firewall settings are changed from below, within 'Edit Security Profile' for specific ESXi host:
ESXi 7.0U3
vCenter 7.0U3
De-selecting any firewall rules, results in disabling the services, most of which are needed for the ESXi host to communicate to vCenter and from the ESXi host to reach storage, impacting the VMs that are hosted.
Performing a reboot, will re-push the default firewall rules needed for communication between ESXi host and vCenter.