NSX Managers are usually deployed in a cluster of 3 NSX Manager appliances. These appliances are usually deployed in the same subnet as other management components such as vCenter Server, and the management IP of ESXi.
If the IP address of the NSX Managers must be changed, there's a procedure to do so, safely.
VMware NSX
The IP address of the NSX appliances needs to be changed.
For NSX version 4.2.x, the procedure to change the IP address of NSX Managers is documented here:
Change the IP Address of an NSX Manager