This article provides diagnostic and resolution procedures for resolving "NFS all paths down" (APD) or "Lost connection to server" errors on NFS datastores. These symptoms commonly occur when end-to-end network path MTU (Maximum Transmission Unit) settings are inconsistent, particularly when Jumbo Frames (MTU 9000) are configured on hosts but restricted by network infrastructure.
On the vCenter Host Summary page, the following error is displayed: "NFS all paths down."
The affected NFS datastore appears as inaccessible and is not connected to the ESXi host in vCenter.
The Storage vMotion migration process can hang or pause unexpectedly at a certain progress percentage.
Storage I/O control operations fail with: "Datastore is not accessible."
VMware vSphere ESXi 7.x
VMware vSphere ESXi 8.x
A configuration mismatch in MTU sizes across the physical network path results in dropped packets, preventing the ESXi host from communicating with the NFS datastore.
var/run/log/VMkernel.log file reports "Synchronous RPC cancel" events followed by "all paths down" errors:YYYY-MM-DDTHH:MM.SSSZ cpu##:32015542)SunRPC: 3291: Synchronous RPC cancel for client 0x431366c02730 IP ##.###.###.##.#.# proc 1 xid 0x26b0a255 attempt 2 of 3YYYY-MM-DDTHH:MM.SSSZ cpu##:32015579)SunRPC: 3291: Synchronous RPC cancel for client 0x431366c02730 IP ##.###.###.##.#.# proc 1 xid 0x26b0b239 attempt 1 of 3YYYY-MM-DDTHH:MM.SSSZ cpu#:2097742)StorageApdHandlerEv: 110: Device or filesystem with identifier [########-########] has entered the All Paths Down state.YYYY-MM-DDTHH:MM.SSSZ cpu#:2097742)StorageApdHandlerEv: 126: Device or filesystem with identifier [########-########] has entered the All Paths Down Timeout state after being in the All Paths Down state for 500 seconds. I/Os will now be fast failed./var/run/log/vobd.log file reports "All Paths Down" followed by "Lost connection to the target":YYYY-MM-DDTHH:MM.SSSZ: [APDCorrelator] 4789768901796us: [vob.storage.apd.start] Device or filesystem with identifier [########-########] has entered the All Paths Down state.YYYY-MM-DDTHH:MM.SSSZ: [APDCorrelator] 4789840782785us: [esx.problem.storage.apd.start] Device or filesystem with identifier [########-########] has entered the All Paths Down state.YYYY-MM-DDTHH:MM.SSSZ: [vmfsCorrelator] 4789992783521us: [vob.vmfs.nfs.server.disconnect] Lost connection to the server ##.###.###.## mount point /Datastorename_ ##.###.###.##, mounted as ########-########-####-############ ("Datastorename_ ##.###.###.##")esxcfg-vswitch -l" to identify the vSwitch used for NFS traffic and check the MTU configured on it.esxcfg-vswitch -lDVS Name Num Ports Used Ports Configured Ports MTU Switch-name #### 8 512 9000
esxcfg-vmknic -l" to verify the MTU set on the VMkernel adapter (vmk).esxcfg-vmknic -lvmk# 15 IPv4 ##.###.###.### ###.###.###.# ##.###.###.### ##:##:##:##:##:## 9000 65535 true STATIC defaultTcpipStackesxcfg-nics -l" to confirm the MTU configured on the physical nics (vmnics).esxcfg-nics -lName PCI Driver Link Speed Duplex MAC Address MTU Descriptionvmnic# ####:##:##.# nenic Up 50000Mbps Full ##:##:##:##:##:## 9000 Cisco Systems Inc Cisco VIC Ethernet NICvmnic# ####:##:##.# nenic Up 50000Mbps Full ##:##:##:##:##:## 9000 Cisco Systems Inc Cisco VIC Ethernet NICvmkping -I vmk# -d -s 8972 ##.###.###.##PING ##.###.###.## (##.###.###.##): 8972 data bytes
--- ##.###.###.## ping statistics ---3 packets transmitted, 0 packets received, 100% packet loss
vmkping to target IP with MTU 1472 works fine.
vmkping -I vmk# -d -s 1472 ##.###.###.##PING ##.###.###.## (##.###.###.##): 1472 data bytes1480 bytes from ##.###.###.##: icmp_seq=0 ttl=128 time=0.504 ms1480 bytes from ##.###.###.##: icmp_seq=1 ttl=128 time=0.453 ms1480 bytes from ##.###.###.##: icmp_seq=2 ttl=128 time=0.494 ms
--- ##.###.###.## ping statistics ---3 packets transmitted, 3 packets received, 0% packet lossround-trip min/avg/max = 0.453/0.484/0.504 ms
Above ping results confirm that host and target communication only works with MTU 1500, and fails with MTU 9000 due to an MTU mismatch in the network path.
Engage the network team to ensure MTU 9000 is configured end-to-end (switch ports, trunk lines, and storage array ports).
Workaround: If infrastructure updates cannot be immediate, temporarily set the MTU to 1500 on the impacted ESXi host VMkernel interface and vSwitch to restore storage stability.
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