When a cluster is managed by vSphere Configuration Profile you are unable to configure NSX on the cluster from the NSX UI.
You are also unable to Configure Virtual Private Cloud through the UI as NSX is Not Configured on cluster:
vSphere 8.x
vSphere 9.x
NSX 4.x
NSX 9.x
Below limitation also blocks the Virtual Private Clouds deployment wizard as we do not have NSX configured on the cluster. In order to get Virtual Private Clouds (VPCs) configured on a VPC enabled cluster you will need to prepare ESX Cluster as TNP as described in resolution.
Using vSphere Configuration Profiles to Manage Host Configuration at a Cluster Level
Limitations to Using vSphere Configuration Profiles:
VCP requires that you manually attach a Transport Node Profile using the Configuration policy from vSphere Cluster Configuration.
Preparing ESX Cluster Hosts as Transport Nodes through vCenter
The VI admin undertakes the following workflow to prepare an ESX cluster as Transport Nodes:
Applying the change to VPC profile for the Cluster by going to Desired state > Draft > nsx > fabric
Based on the limitations of using VCPs you cannot enable NSX config on the cluster from the NSX UI.