VMs can become inaccessible if storage policy is set to no data redundancy (FTT=0) and there is a single point of failure such as the host/disk/diskgroup.
If no data redundancy (FTT=0) is used as a storage policy on any of the VMs on the vSAN environment where either a single host, disk or disk group failure occurs, there is a risk of data becoming unavailable.
If a vSAN host/disk/diskgroup is down where FTT=0 (no data redundancy) objects reside on, try get the host/disk/diskgroup back online and this should bring the VMs back online. If this fails, a restore of VMs from the backups will need to be performed.
It's not recommended to use FTT=0 (No data redundancy) storage policy on production VMs, as any failure can potentially cause some VMs to become inaccessible.
It is recommended to use a Storage Policy with RAID 1, 5, or 6 for production level VMs, so a single failure can be withstood without an impact to production.