When creating a vSphere Replication site pairing, the following error is thrown:
Unable to connect to Lookup Service at https://vCenterIP-or-FQDN:443/lookupservice/sdk. Reason:
https://vCenterIP-or-FQDN:443/lookupservice/sdk invocation failed with "java.net.NoRouteToHostException: No route to host (Host unreachable)"
vSphere Replication 9.0+
vSphere Replication 8.6+
As the error message indicates, there is no networking route established from the vSphere Replication appliance to the Peer vCenter via port 443.
When running an curl -v telnet command from an SSH session from the vSphere Replication appliance to the Peer vCenter via port 443 shows the following output:
Typically, this error message indicates that the network that the vSphere Replication appliance is on cannot route to the network that the Peer vCenter is on.
Or this error message can indicate that the port 443 is being blocked by a firewall between the vSphere Replication appliance and the Peer vCenter.
Ensure port 443 is open in both directions from the vSphere Replication appliance and the Peer vCenter.
To allow the ports and validate network configurations, engage switch / firewall vendor.
See the following KB article for more information on what ports need to be open for vSphere Replication to work properly: