High CPU usage on the ESXi host where the NSX Manager VM is running.
The NSX Manager functionality can be restored by moving the VM to a different, healthy host and rebooting it. Verify the original host is healthy and not overprovisioned or over-utilized before moving any NSX VM back to it.
Note that snapshots of NSX Manager Appliance VMs should not ever be taken as explained at Disable Snapshots on an NSX Appliance. However, because the CPU lockup state can also come about due to snapshot quiesce actions, make sure that no snapshots are present.
Refer also to vSphere ESXi article, Error: "kernel: BUG: soft lockup - CPU#Y stuck for Xs" within VM, regarding the same condition for VMs generally, not specific to NSX environments.